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Wedbush analysts doubled their estimates for Omeros's eyedrug's potential penetration in the United States, citing U.S.Food and Drug Administration rules that would restrict the useof similar drugs used in lens replacement surgery.
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“We can’t accept this,” he said. “There is nothing normal about innocent men and women being gunned down where they work. There is nothing normal about our children being gunned down in their classrooms. There is nothing normal about children dying in our streets from stray bullets.”
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"Securing the safety and improving the wellbeing of children is at the heart of all of our work to make Scotland the best place in the world to grow up for every child, regardless of their background or circumstances.
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Elsewhere in the Atlantic, Tropical Storm Gabrielle ismoving north with sustained winds of 40 miles (65 kilometers)per hour and is expected to brush Nova Scotia sometime tomorrow,according to the hurricane center.
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We are so used to politics being a dirty, compromised business that it’s a shock to see this young woman make it a noble vocation. Only through politics, she realised, was it possible to alter a society that didn’t value girls. “Don’t worry, next time you can have a boy,” relatives and friends told her mother when Malala was born. Her father, a headteacher, said that, unlike other Pakistani men, “I accepted her as an individual. I did not treat her as property. Educate your daughters: they’re amazing!”

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Bo was sacked as Communist Party chief of the southwestern city of Chongqing last year when his wife was named as an official suspect in the November 2011 murder of Heywood, a long-time friend of the couple who also helped their son, Bo Guagua, settle into study in Britain.
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The fourth-year infielder also angered the organization by showing up to spring training overweight and out of shape, but Terry Collins said Tejada will get a chance to play over the final three weeks of the season, with the possibility that he still will be considered for a starting spot in 2014 and beyond.
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* CN Railway Co : BMO raises price target to C$119from C$115, expect the company's revenue growth rate toaccelerate to over 8 percent in 2014 and earnings per sharegrowth to be in the mid-to-high teens including the contributionfrom share repurchase programs.
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The 20-year-old singer, whose latest "We Can't Stop" single is currently No. 2 on the Billboard charts, said she was not like other young celebrities who become obsessed with public image and self-destruct under the pressure of media scrutiny.
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Wireless carrier AT&T Inc, which rolled out its home security and automation service in 2011, is planning to offer services in more than 50 markets by the end of 2013, ahead of their original plan, and go national in 2014. Glenn Lurie, the head of AT&T's emerging devices business, said such services could eventually reap $1 billion a year.

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Parcells showed his many sides during his unscripted 20-minute speech: He was philosophical, informative, educational, especially on the dynamics of life in the locker room; he was thankful to his ex-wife and three daughters for their support of a nomadic coaching life, and to the owners, players and coaches from his 19 years of being a head coach in the NFL and two stints as an executive.
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Ales are poured beneath the cogs and wheels of this former 18th-century flour mill, while outside the River Dee gushes right beside the cosy, beamed dining-rooms. Braised shoulder of lamb comes with caponata and rich garlicky mash (£16.75)
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Under Obama's Deferred Action for Childhood Arrivals program, immigrants who came to the United States as children and meet certain other criteria can apply for a work permit for a renewable period of two years.
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Chris Grayling made clear his dismay after Mr Justice Sweeney said that a ruling in Strasbourg meant that a British law used to ensure that the most notorious killers are never released from jail breached their human rights.
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"Today's swearing in is an important stage in the future of the Central African Republic and I hope I am the last of my countrymen to have to take up arms in order to come to power," Djotodia said in a speech during the ceremony.

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At least six members of Sunni militias opposed to al-Qaida were also killed Saturday. The militiamen were members of the Sahwa, which joined U.S. troops in the fight against al-Qaida at the height of Iraq war. Its members have since been frequently targeted by Sunni insurgents, who consider them traitors.
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Earnings came to $2.10 per share, excluding favorable taxbenefits and net investment gains, up from $2.09 a year earlier.Analysts on average were expecting a profit of $1.82 per share,according to Thomson Reuters I/B/E/S.
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"We love being in the Neill Blomkamp business," said Rory Bruer, president of world-wide distribution at Sony Pictures Entertainment. The studio is talking with the director about working together on other projects, he said.
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Maria Miller, the Culture Secretary, told the Commons yesterday that a committee of the Privy Council had rejected the newspaper industry’s petition for the granting of a Royal Charter “because it falls short of government policy on the self-regulation of the press, based on the Leveson report”. The politicians have devised their own structures, also to be enshrined in Royal Charter, but one that they seek to impose upon the press.
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Anyone interested in vegetarian eating should check out  Tuesday’s ABC health tweet chat moderated by Dr. Richard Besser, ABC News’ chief health and medical correspondent. Besser, along with Whole Foods, the Center for Science in the Public Interest, registered dietitians, bloggers, and other veggie lovers, tweeted out great tips and information to help anyone become a healthy, happy vegetarian.

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"I have been making it clear to Con Ed and the MTA that adelay like the one they initially proposed was completelyunacceptable," he said. "I want to reemphasize that they need toalleviate this problem as quickly as possible."
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So we spoke to Dr. Norton, a professor at Harvard Business School, to find out what little tricks we can do — like splurging on a nice dinner out with friends, instead of shelling out for a high-def TV — to score the most happiness bang for our buck.
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Taxable Build America Bonds, created in the 2009 economicstimulus plan, pay issuers federal rebates equal to 35 percentof the bonds' interest costs. The rebates were so attractivethat state and local governments rushed to sell $181 billionBABs in the 20 months of the program's existence.
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Among blacks, 63% want more charters. Among New Yorkers earning less than $50,000, 64% want more. In other words, many of those chronically disadvantaged by traditional public schools are yearning for quality alternatives.
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The fund, co-founded by finance industry veteran Jeff Ubben in 2000, has made a reputation for building stakes in companies and working with management in private to change fundamental strategy. ValueAct's other major holdings include Adobe Systems Inc, Motorola Solutions Inc and Valeant Pharmaceuticals International Inc.

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Apple's former retail chief Ron Johnson, who had a brief and disastrous stint as CEO of JC Penney after leaving Apple in 2011, made $29.8 million in 2010. He is credited with building Apple's retail network from scratch in his decade-long stint.
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Dividends from American shares will be taxed by the US authorities at 30pc, or 15pc if you hold the shares through a “qualified intermediary” such as a stockbroker. Holdings in pensions are exempt from the tax but those in Isas are not. Alternatively, you can sign a form called IRS W-8BEN that entitles you to a lower rate of tax. You should be able to download this form from your stockbroker’s website. Hargreaves Lansdown offers this service and insists you submit the form before trading in US shares.
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"If a cut in export subsidies could be partly justified sixmonths ago, it makes no sense today in a market that has sharplydeteriorated and with the Brazilians that are doing massivedumping," Christian Marinov, head of the French poultryassociation, said. ($1 = 0.7639 euros) (Reporting by Pierre-Henri Allain, additional reporting byCharlie Dunmore in Brussels; writing by Sybille de La Hamaide;editing by Jane Baird)
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The three state-owned companies had not raised complaintsbecause they knew the decision had been endorsed by Chineseleadership including Premier Li Keqiang, who has backed theShanghai FTZ, the sources added.
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Charlotte Leslie, a Conservative member of the Commons health select committee, said: “It does seem like we need to look quite seriously at the processes of the GMC. In too many cases the GMC doesn’t root out the bad eggs.”

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The Daily News has some of the most memorable photos in sports history. From legendary boxers and iconic tennis players to golfing greats and fabled Olympians, the Daily News has the photos you want of the once-in-a-lifetime sports moments. Find yours today and relive history.
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The stakes went up last week, when big aluminum buyers represented by MillerCoors - America's second-largest brewer - told senators that banks' control of metals warehouses drove up the brewers' costs by as much as $3 billion last year.
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Tiles at the mall were smeared with blood, bullet casingswere strewn on the floor and shop windows were shattered. Apoliceman dragged the corpse of a young girl across the floorand laid her on a stretcher. Two policemen lay on the floor withguns trained on the supermarket entrance.
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The 53-year old actor, who spoke to The Associated Press on Saturday night, expressed satisfaction that the organization continues to rebuild Haiti with its medical, relocation, structural and community development programs -but also that it brings hope to the island nation.
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Saratoga Race Course opened as planned for the debut day of the thoroughbred racing season, but extra precautions were in place to take care of the horses. Veterinarians were stationed on the paths while extra ice buckets and water were placed in the jockeys' quarters.

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A Washington state man told his father during a jailhouse phone call that he killed his 3-year-old son after taking pills and running out of gas on a remote road in southwestern Montana, prosecutors said in new court documents.
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WASHINGTON (AP) — An internal investigation of President Barack Obama's choice to be the No. 2 official at the Homeland Security Department has the potential to become a political headache for former Secretary of State Hillary Rodham Clinton and the Democratic candidate for governor in Virginia.
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The agency, called the Single Resolution Mechanism (SRM), isto complement the European Central Bank as part of a bankingunion that will break the vicious circle between weak banks andindebted governments.
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In an attempt to blend the good old days with family life, parents will often frequent swanky eateries with youngsters in tow. At the risk of sounding a little bit Victorian, surely there are some safe havens where children should be neither seen or heard?
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The piece also raises larger questions: Are patients who shouldn’t be in assisted living admitted anyhow to boost the bottom line? Did Emeritus facilities chronically skimp on staffing and training because of corporate pressure to make their numbers? Should the industry be regulated more strictly?

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FBI and other federal agents first tapped into the site in November 2011 and have made more than 100 undercover purchases of controlled substances, including Ecstasy, cocaine, heroin and LSD, on the network. The drugs came from vendors located in the United States and at least 10 other countries, court papers say. Agents also purchased hacking services, including malicious software such as password-stealing programs, the court papers say.
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While most Saudi officials have in public insisted they arenot worried by the shale threat, the Organization of thePetroleum Exporting Countries (OPEC) has recognised that itneeds to address the issue.
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Mrs Bull told the Western Daily Press: "Last winter was terrible. We were actually shivering and were hungry. In 2013, two people who worked all their lives at this have ended up cold and hungry. It's not right.
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In the course of investigating Lloyd's death, authorities found a vehicle at the home of Hernandez's uncle in Bristol, Conn., Hernandez's hometown, that was wanted in a 2012 double killing in Boston, according to the Florida records. It had been rented in Hernandez's name.
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NOTES: RW Cal Clutterbuck played his first game with the Islanders. He was acquired in an offseason trade from Minnesota, then sat out the first three games this season with a leg laceration. . Khabibulin was Chicago’s No. 1 goaltender for four seasons, from 2005-09. . The 21-year-old Nordstrom played in his fourth NHL game. . Both teams play again on Saturday night. The Blackhawks host Buffalo and the Islanders are at Nashville.

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"My day would normally consist of bringing the guests their coffee in the morning so they can start getting their thoughts together," Mattinson says. "Then we find out whether they're going to go golfing or skiing, we help them arrange transportation, get them to the valet, run back for forgotten items in the room and generally make sure they are tended to. We are always available via phone or text."
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Outrage erupted on Twitter and other social media sites lastyear after consumers found out that everything from U.S. schoollunches to fast-food hamburgers used so called "lean finelytextured beef," a low-fat product made from chunks of beef,including trimmings, and exposed to tiny bursts of ammoniumhydroxide to kill E. coli and other dangerous contaminants. Theresulting media storm over what critics dubbed "pink slime"nearly destroyed the product's maker, even though U.S. foodsafety regulators said it was safe.
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Investors flocked to housing-related stocks on bets ofdownward pressure on mortgage rates. The PHLX housing index jumped 2.9 percent. Among individual stocks, D.R. Horton jumped 4.1 percent to $19.89.
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Biden was slated to lead a group of dignitaries also set to include U.S. Homeland Security Secretary Janet Napolitano and Arizona Governor Jan Brewer, as well as representatives of fire departments from across the United States. Biden and Brewer will speak at the event.
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* With the government shutdown heading toward a second week,economists say it could hold back economic growth, businessconfidence and corporate earnings, but probably won't cause arecession. Many money managers doubt the damage will be lasting.Any stock selloff, they say, would be a great buyingopportunity. ()